کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
871784 910199 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage
ترجمه فارسی عنوان
یک مطالعه خستگی تجربی از یک داربست متخلخل برای بازسازی غضروف مفصلی
کلمات کلیدی
مهندسی بافت، داربست، خواص مکانیکی مواد زیستی، پیش بینی خستگی، بازسازی غضروف
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی

The aim of this experimental study is to predict the long-term mechanical behavior of a porous scaffold implanted in a cartilage defect for tissue engineering purpose. Fatigue studies were performed by up to 100,000 unconfined compression cycles in a polycaprolactone (PCL) scaffold with highly interconnected pores architecture. The scaffold compliance, stress–strain response and hysteresis energy have been measured after different number of fatigue cycles, while the morphology has been observed by scanning electron microscopy at the same fatigue times. To simulate the growing tissue in the scaffold/tissue construct, the scaffold was filled with an aqueous solution of polyvinyl alcohol (PVA) and subjected to repeating cycles of freezing and thawing that increase the hydrogel stiffness. Fatigue studies show that the mechanical loading provokes failure of the dry scaffold at a smaller number of deformation cycles than when it is immersed in water, and also that 100,000 compressive dynamic cycles do not affect the scaffold/gel construct. This shows the stability of the scaffold implanted in a chondral defect and gives a realistic simulation of the mechanical performance from implantation of the empty scaffold to regeneration of the new tissue inside the scaffold׳s pores.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 48, Issue 7, 1 May 2015, Pages 1310–1317
نویسندگان
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