کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
872003 910217 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Distribution of aerosolized particles in healthy and emphysematous rat lungs: Comparison between experimental and numerical studies
ترجمه فارسی عنوان
توزیع ذرات فشرده در ریه های ریه های سالم و امگیزیمته: مقایسه بین مطالعات تجربی و عددی
کلمات کلیدی
جریان هوا، رسوب ذرات، چند مقیاس، تجربیات قرار گرفتن در معرض آئروسل، دینامیک سیالات محاسباتی
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی

In silico models of airflow and particle deposition in the lungs are increasingly used to determine the therapeutic or toxic effects of inhaled aerosols. While computational methods have advanced significantly, relatively few studies have directly compared model predictions to experimental data. Furthermore, few prior studies have examined the influence of emphysema on particle deposition. In this work we performed airflow and particle simulations to compare numerical predictions to data from our previous aerosol exposure experiments. Employing an image-based 3D rat airway geometry, we first compared steady flow simulations to coupled 3D–0D unsteady simulations in the healthy rat lung. Then, in 3D–0D simulations, the influence of emphysema was investigated by matching disease location to the experimental study. In both the healthy unsteady and steady simulations, good agreement was found between numerical predictions of aerosol delivery and experimental deposition data. However, deposition patterns in the 3D geometry differed between the unsteady and steady cases. On the contrary, satisfactory agreement was not found between the numerical predictions and experimental data for the emphysematous lungs. This indicates that the deposition rate downstream of the 3D geometry is likely proportional to airflow delivery in the healthy lungs, but not in the emphysematous lungs. Including small airway collapse, variations in downstream airway size and tissue properties, and tracking particles throughout expiration may result in a more favorable agreement in future studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 48, Issue 6, 13 April 2015, Pages 1147–1157
نویسندگان
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