کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8731276 1590392 2018 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Probiotics and fecal microbiota transplantation in surgical disorders
ترجمه فارسی عنوان
پروبیوتیک ها و پیوند میکروب بیوت مدفوع در اختلالات جراحی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی
The importance of the gut microbiota in health and disease has led to interest in developing methods to modify it. Probiotics administration and fecal microbiota transplantation (FMT) are two such approaches that can alter the gut microbiota, potentially offering health benefits by blocking gut colonization by pathogenic organisms and preventing a maladaptive immune response. Both methods have been studied in a variety of settings relevant to colorectal surgeons, including colorectal cancer, inflammatory bowel disease, Clostridium difficile colitis, and surgical site infections. However, both therapies offer risks and benefits in surgical patients. Probiotics allow for targeted alterations of the microbiome, but lingering questions remain regarding strain selection. FMT offers to more completely restore the healthy gut microbial ecosystem but it is difficult to study in animals and to determine its precise mechanism of action. Standardizing study methodologies and using modern molecular and genetic techniques to elucidate the mechanisms of action will be needed to determine the role of probiotic administration and FMT in treating or preventing complications in patients undergoing major abdominal surgery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Colon and Rectal Surgery - Volume 29, Issue 1, March 2018, Pages 37-43
نویسندگان
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