Oxidative stress is associated with increased arterial stiffness in middle-aged and elderly community-dwelling persons

Both right and left baPWV values of Tertile-2 (61-81 U/L) and Tertile-3 (82-218 U/L) categorized by tertiles of the MDA-LDL level were significantly higher than those of Tertile-1 (34-60 U/L; p = 0.022 and p = 0.018, respectively). The multivariate-adjusted baPWV increased significantly from the lowest to the highest MDA-LDL group. Both baPWV values of Tertile-2 (61-81 U/L) and Tertile-3 (82-218 U/L) were significantly higher than those of Tertile-1 (34-60 U/L) (p = 0.044 and p = 0.044, respectively). To further investigate whether MDA-LDL can explain baPWV levels independent of other known confounding factors, multiple linear regression analyses for baPWV were conducted, which showed that MDA-LDL levels (β = 0.164, p = 0.037) were independently and significantly associated with baPWV as well as gender, age, and presence of raised blood pressure. In addition, we found that a slightly high-normal MDA-LDL level within a normal range is significantly associated with a higher baPWV. MDA-LDL levels are associated with an increased risk of arterial stiffness in community-dwelling persons.