کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
874289 910331 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term lowering of tumour interstitial fluid pressure reduces Ki-67 expression
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Long-term lowering of tumour interstitial fluid pressure reduces Ki-67 expression
چکیده انگلیسی

High tumour interstitial fluid pressure (TIFP) is a characteristic of most solid tumours. Recent data give first evidence that mechanical stretch induced by TIFP triggers proliferation in solid tumours. In the present study we compared two protocols of TIFP reduction on the expression of the tumour proliferation marker Ki-67: (a) short-term lowering of TIFP by a singular puncture and (b) long-term lowering of TIFP by catheterization. Utilizing two experimental tumours (A431, A549) it was found that the TIFP broke down rapidly after a singular puncture but recovered within 6 h. In case of permanent catheterization no TIFP recovery was observed. After 24 h tumours were excised and stained against the proliferation marker Ki-67. While a singular puncture had no effect catheterized tumours showed a significant decrease in Ki-67 expression. Our data suggest that long-term lowering of TIFP is required to reduce tumour proliferation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 40, Issue 10, 2007, Pages 2324–2329
نویسندگان
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