Peamacléine Pru p 7 : épidémiologie, implications cliniques et place dans le diagnostic moléculaire de l'allergie à la pêche en région méditerranéenne

Molecular-based allergy diagnostic kits using standard IgE reagents such as peach extract, Pru p 1 (PR-10), Pru p 3 (non-specific lipid transfer protein), Pru p 4 (profilin), and cross-reactive carbohydrate determinants, are unable to identify the offending allergen in certain patients with peach allergy in Southern France, despite positive skin tests and a convincing clinical history. The constant and high positivity of the basophil activation test with peach extract in such patients suggests the involvement of a molecular peach allergen not included in existing in vitro diagnostic kits. Herein we report that peamaclein (Pru p 7) is a major allergen in peach-allergic patients in the Mediterranean (Marseille) region and we describe the epidemiological, clinical and laboratory characteristics associated with this novel allergen.