کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
874861 910352 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanical mechanisms of thrombosis in intact bent microvessels of rat mesentery
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Mechanical mechanisms of thrombosis in intact bent microvessels of rat mesentery
چکیده انگلیسی

The hypothesis that thrombus can be induced by localized shear stresses/rates, such as in the bent/stretched microvessels, was tested both experimentally and computationally. Our newly designed in vivo experiments were performed on the microvessels (post-capillary venules, 20–50 μm diameter) of rat mesentery. These microvessels were bent/stretched with no/minimum injuries. In less than 60 min after the microvessels were bent/stretched, thrombi were formed in 19 out of 61 bent locations (31.1%). Interestingly, thrombi were found to be initiated at the inner wall of the curvature in these bent/stretched vessels. To investigate the mechanical mechanisms of thrombus induction, we performed a 3-D computational simulation using commercial software, FLUENT. To simulate the bending and stretching, we considered the vessels with different curvatures (0°, 90° and 180°) as well as different shaped cross-sections (circular and elliptic). Computational results demonstrated that the highest shear stress/rate and shear stress/rate gradient are located at the inner wall of the curved circular-shaped vessels. They are located at the two apexes of the wall with shorter axis for the 0° (straight) elliptic-shaped vessel and towards the inner side when the vessels are bent. The differences of the shear stresses/rates and of the shear stress/rate gradients between the inner and outer walls become larger in more bent and elliptic-shaped microvessels. Comparison of our experimental and numerical simulation results suggests that the higher shear stress/rate and the higher shear stress/rate gradient at the inner wall are responsible for initiating the thrombosis in bent post-capillary venules.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 41, Issue 12, 28 August 2008, Pages 2726–2734
نویسندگان
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