کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8753132 1594870 2017 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cell-free DNA, inflammation, and the initiation of spontaneous term labor
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Cell-free DNA, inflammation, and the initiation of spontaneous term labor
چکیده انگلیسی
Spontaneous labor at term is associated with a greater cell-free DNA methylation ratio and interleukin-6 compared with nonlabored controls. As gestation advances, total cell-free DNA concentrations and interleukin-6 levels increase. A greater methylation ratio reflects a greater maternal contribution (vs placental) in women with labor, likely resulting from greater levels of neutrophils, lymphocytes, and uterine activation proteins at the time of labor. Although not significant, women in labor had a greater total cell-free DNA concentration and thus could theoretically have more hypomethylated DNA available for interaction with the inflammatory cascade. Larger studies are needed to investigate this theory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Obstetrics and Gynecology - Volume 217, Issue 5, November 2017, Pages 583.e1-583.e8
نویسندگان
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