کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8756609 | 1596233 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Multifocal hyperfunctioning thyroid carcinoma without metastases
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
Hyperthyroidism due to thyroid carcinoma is rare, and most cases are caused by hyperfunctioning metastatic thyroid carcinoma rather than primary carcinoma. Among primary hyperfunctioning thyroid carcinoma, multifocal thyroid carcinoma is exceedingly rare, with the only one case being reported in the literature. Here, we describe the case of a 62-year-old woman with multifocal functioning thyroid carcinoma. Technetium-99Â m (99mTc) scintigraphic imaging showed four hot areas in the thyroid gland. Histopathological examination of all four nodules revealed papillary carcinoma, corresponding to hot areas in the 99mTc scintigram. DNA sequencing of the thyrotropin receptor (TSH-R) gene from all nodules revealed no mutation, indicating that activation of TSH-R was unlikely in the pathophysiogenesis of hyperfunctioning thyroid carcinoma in the present case.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Auris Nasus Larynx - Volume 35, Issue 3, September 2008, Pages 432-436
Journal: Auris Nasus Larynx - Volume 35, Issue 3, September 2008, Pages 432-436
نویسندگان
Akiko T. Nishida, Shigeru Hirano, Ryo Asato, Shinzo Tanaka, Yoshiharu Kitani, Nobumitsu Honda, Nobuya Fujiki, Kouji Miyata, Hideyuki Fukushima, Juichi Ito,