کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8764077 | 1597467 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Advances in systemic lupus erythematosus
ترجمه فارسی عنوان
پیشرفت در لوپوس اریتماتیک سیستمیک
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a heterogeneous course and systemic involvement. It is the result of a complex pathogenic pathway that culminates in autoantibody formation. The interaction between environmental triggers and genetic susceptibility is key in this process. Genome-wide association study technology has allowed the recognition of >80 loci associated with SLE that lead to the formation of key proteins, each contributing a small increase to the risk. Advances in the management of the disease include new validated standardized tools to capture disease activity, damage and quality of life, for clinical and research purposes. The prognosis of SLE has much improved in the last 50 years because of better general management and specific treatment, including better use of immunosuppressive agents and development of a new group of drugs - biological therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medicine - Volume 46, Issue 2, February 2018, Pages 84-92
Journal: Medicine - Volume 46, Issue 2, February 2018, Pages 84-92
نویسندگان
Su-Ann Yeoh, Sofia Sapeta Dias, David A. Isenberg,