کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8764679 1597673 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metabolomics for the masses: The future of metabolomics in a personalized world
ترجمه فارسی عنوان
متابولومیک برای توده ها: آینده متابولومیکس در یک دنیای شخصی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی
Current clinical practices focus on a small number of biochemical directly related to the pathophysiology with patients and thus only describe a very limited metabolome of a patient and fail to consider the interations of these small molecules. This lack of extended information may prevent clinicians from making the best possible therapeutic interventions in sufficient time to improve patient care. Various post-genomics '('omic)' approaches have been used for therapeutic interventions previously. Metabolomics now a well-established'omics approach, has been widely adopted as a novel approach for biomarker discovery and in tandem with genomics (especially SNPs and GWAS) has the potential for providing systemic understanding of the underlying causes of pathology. In this review, we discuss the relevance of metabolomics approaches in clinical sciences and its potential for biomarker discovery which may help guide clinical interventions. Although a powerful and potentially high throughput approach for biomarker discovery at the molecular level, true translation of metabolomics into clinics is an extremely slow process. Quicker adaptation of biomarkers discovered using metabolomics can be possible with novel portable and wearable technologies aided by clever data mining, as well as deep learning and artificial intelligence; we shall also discuss this with an eye to the future of precision medicine where metabolomics can be delivered to the masses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: New Horizons in Translational Medicine - Volume 3, Issue 6, March 2017, Pages 294-305
نویسندگان
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