کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8776763 | 1599340 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dosage-dependent reduction of macular pigment optical density in female breast cancer patients receiving tamoxifen adjuvant therapy
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
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چکیده انگلیسی
It is now increasingly common for breast cancer patients to receive adjuvant tamoxifen therapy for a period of up to 10 years. As survival rate increases, managing tamoxifen ocular toxicities is important for patients' quality of life. Macular pigments in photoreceptor cells protect against free radical damage, which can cause macular degeneration. By reducing macular pigment concentration, tamoxifen may increase the risk of macular degeneration. Here, we compared macular pigment optical density (MPOD) and central macular thickness between breast cancer patients on tamoxifen adjuvant therapy (nâ¯=â¯70), and a control group (nâ¯=â¯72). Multiple regression analysis indicated that MPOD decreases with increasing tamoxifen dosage, up to a threshold of about 20â¯g, after which MPOD plateaus out. Mean MPOD in the treatment group (meanâ¯=â¯0.40) was significantly lower (p-valueâ¯=â¯0.02) compared to the control group (meanâ¯=â¯0.47) for the left eye, and for the right eye (treatment meanâ¯=â¯0.39; control meanâ¯=â¯0.48; p-valueâ¯=â¯0.009). No significant difference in mean central macular thickness was found between the treatment and the control group (p-valuesâ¯>â¯0.4). In the control group, MPOD and central macular thickness showed significant correlation (râ¼0.30; p-valuesâ¯<â¯0.01) for both eyes. However, in the treatment group, loss of significant correlation was observed in the left eye (râ¯=â¯0.21; p-valueâ¯=â¯0.08). The present results show that MPOD decreases non-linearly as a function of tamoxifen dosage, and highlight the potential of tamoxifen to reduce macular pigment concentration through an unknown mechanism that does not depend on macular thinning solely.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 39, June 2018, Pages 117-122
Journal: The Breast - Volume 39, June 2018, Pages 117-122
نویسندگان
I-Liang Lim, Angela Voon Pei Loo, Visvaraja Subrayan, Tsung Fei Khang, Mee Hoong See, Adlinda Alip, Nur Aishah Mohd Taib,