Human Papilloma Virus, Histopathological, and Molecular Subtyping in Penile Cancer: Relevance for Prognosis and Therapy

The histopathological subtype should be documented and considered for prognostic evaluation in patients with penile SCC. The prognostic value of HPV infection has to be investigated in larger cohorts considering the histopathological subtype. Further molecular studies have to identify relevant molecular subtypes and to develop type-specific targeted therapies.