Hormonal strategies in gynecologic cancer: Bridging biology and therapy

- Hormonal signaling is active in gynecologic tumors and involves tumor-stroma crosstalk.
- Progestins and aromatase inhibitors with mTOR inhibitors are clinically active in metastatic ER+/PR+ endometrial cancer.
- Systemic or local progestins enable fertility sparing in young women with early stage endometrial cancer.