Racial disparities in molecular subtypes of endometrial cancer

Progression-free survival in White (A, C, E) or Black (B, D, F) endometrial cancer patients with versus without the copy number variant (CNV)-high subtype (A, B), the somatic copy number alterations (SCNA) cluster 4 subtype (C, D), or the transcript-based mitotic subtype (E, F). Survival distributions compared using log-rank testing. Bar chart displaying the proportion of patients with the more-aggressive copy number variant (CNV)-high subtype, the somatic copy number alterations (SCNA) cluster 4 subtype, or the transcript-based mitotic subtype (G). Fisher's exact testing was used to compare categorical variables. Venn diagram of the most significantly up-regulated transcripts in cell cycle signaling and in pathways in cancer in Black and/or in White endometrial cancer patients with mitotic versus non-mitotic subtypes with > 2-fold change elevation and a false discovery rate < 0.01 (H).263