کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8780610 1600068 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ROR1 and ROR2 play distinct and opposing roles in endometrial cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
ROR1 and ROR2 play distinct and opposing roles in endometrial cancer
چکیده انگلیسی
ROR1 and ROR2 play distinct roles in endometrial cancer. ROR1 may promote tumor progression, similar to its role in ovarian cancer, while ROR2 may act as a tumor suppressor in endometrioid endometrial cancer, similar to its role in colorectal cancer. With several ROR-targeting therapies currently in development and phase I clinical trials for other tumor types, this study supports the potential of these receptors as therapeutic targets for women with endometrial cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 148, Issue 3, March 2018, Pages 576-584
نویسندگان
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