Indução de ovulação em pacientes com tumor estrogênio‐dependente: diretrizes clínicas da Sociedade Brasileira de Reprodução Humana

Oncofertility is an interdisciplinary interest field of recent development, which aims to merge the knowledge in oncology and reproductive medicine, with the help of assisted reproductive technologies, to develop strategies for gonadal function preservation and to offer the possibility of biological procreation to cancer survivors. Preservation strategies of female fertility in oncological patients currently accepted for routine practice are the cryopreservation of embryos and cryopreservation of mature oocytes. It happens that ovulation induction is mandatory for executing both strategies, and with it the theoretical risk of stimulation of estrogen‐dependent tumors growth and the postponement of anti‐neoplastic treatment. Random‐start ovarian stimulation protocols include the intention of minimizing the delay in onset of chemo‐radiotherapy and to block tumor growth, providing satisfactory results, similar to those obtained in the usual beginning protocols. This article presents the clinical guidelines of the Brazilian Society of Human Reproduction for ovulation induction in patients with estrogen‐dependent tumors.