Medicare Spending on Anti-Vascular Endothelial Growth Factor Medications

The number of anti-VEGF injections performed annually, and their associated costs, continue to rise. Ranibizumab and aflibercept costs account for 12% of the Medicare Part B budget annually. Bevacizumab represents a substantially more cost-effective alternative, but its use can present many obstacles, including efficacy concerns, dependence on compounding pharmacies, and off-label usage.