کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8807155 | 1606459 | 2018 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Microvessel density and cell proliferation in juvenile ossifying fibroma: A comparative study with central ossifying fibroma
ترجمه فارسی عنوان
تراکم میکرووکسل و تکثیر سلولی در فیبروما آسیب شناخته شده نوجوانان: یک مطالعه تطبیقی با فیبروما آسیب شناسی مرکزی
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
چکیده انگلیسی
Considered as an aggressive counterpart of central ossifying fibroma (OF), juvenile ossifying fibroma (JOF) is a benign fibro-osseous neoplasm characterized by an unpredictable destructive behavior, elevated morbidity, mutilating treatment and high potential for local recurrences. The aim of this study is to compare the analysis for cell proliferation and vascular markers between JOF and OF. Cell proliferation index was measured by Ki-67 and Mcm-2 expression and microvessel density (MVD) was obtained by the immunoexpression of CD34/CD105. We observed a reduced expression of vascular markers, where MVD for CD34 was significantly higher in JOF than in OF (pâ¯=â¯0.009), but no statistical difference was found for CD105. JOF and OF showed low expression for Ki-67 and Mcm-2 and no difference was noted between both, suggesting that other mechanisms such as anti-apoptotic and/or pro-autophagic pathways or even increased expression of matrix metalloproteinases may be responsible for the aggressiveness of JOF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Diagnostic Pathology - Volume 36, October 2018, Pages 44-49
Journal: Annals of Diagnostic Pathology - Volume 36, October 2018, Pages 44-49
نویسندگان
João Augusto Vianna Goulart-Filho, Victor Angelo Martins Montalli, FabrÃcio Passador-Santos, Andresa Borges Soares, Ney Soares de Araújo, Vera Cavalcanti de Araújo,