کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8807172 1645515 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Should we excise? Are there any clinical or histologic features that predict upgrade in papillomas, incidental or non-incidental?
ترجمه فارسی عنوان
آیا ما باید مالیات دهیم؟ آیا ویژگی های بالینی یا بافت شناسی وجود دارد که پیش بینی می شود در پاپیلوم ها ارتقا پیدا کند، به طور اتفاقی یا غیر تصادفی؟
کلمات کلیدی
پاپیلوم داخل پستانداران تصادفی غیر عادی، کارسینوم داکتال در محل، هیپرپلازی مجاری غیرطبیعی، ارتقاء
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
چکیده انگلیسی
The clinical decision to excise intraductal papilloma (IDP) without atypia diagnosed on biopsy remains controversial. We sought to establish clinical and histologic predictors (if any) which may predict upgrade in IDP. 296 biopsies (in 278 women) with histologic diagnosis of IDP without atypia were retrospectively identified and placed into Incidental (no corresponding imaging correlate), or Non-incidental (positive imaging correlate) groups. 253/296 (85.5%) cases were non-incidental, and 43/296 (14.5%) were incidental. 73.1% (185/253) non-incidental and 48.8% (21/43) incidental cases underwent excision. 12.4% (23/185) non-incidental cases underwent an upgrade to cancer or high-risk lesion; namely 8-Ductal carcinoma in situ (DCIS), 8-atypical ductal hyperplasia (ADH), 6-lobular neoplasia, and 1-flat epithelial atypia. There was no histopathologic feature on the biopsy in the non-incidental group which predicted upgrade; however a past history of atypia was significantly associated with upgrade. 2 of the 21 incidental cases upgraded (1 to ADH and 1 to lobular neoplasia); the former had a past history of ADH. Both incidental upgrades were >1 mm in size, and were not completely excised on the biopsy. None of the incidental cases which appeared completely excised on biopsy upgraded, irrespective of the size on biopsy. These findings suggest that all non-incidental IDPs should be considered candidates for surgical excision, given the 12.4% upgrade rate and no definitive histologic predictors of upgrade. Patients with incidental IDPs (if <1 mm, completely excised on biopsy and with no history of high risk breast lesion) can be spared excision.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Diagnostic Pathology - Volume 35, August 2018, Pages 62-68
نویسندگان
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