کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8807437 | 1606631 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases
ترجمه فارسی عنوان
کارسینوم سلول های کوچک مثانه ادراری: یک بررسی بالینی و ایمونوهیستوشیمی از 81 مورد
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
چکیده انگلیسی
Small cell carcinoma (SmCC) of the bladder is a rare disease. We retrospectively studied a large series of bladder SmCC from a single institution. The patients included 69 men and 12 women with a mean age of 68â¯years. Most bladder SmCCs were presented at advanced stage, with tumors invading the muscularis propria and beyond (nâ¯=â¯77). SmCC was pure in 27 cases and mixed with other histologic types in 54 cases, including urothelial carcinoma (UC) (nâ¯=â¯32), UC in situ (nâ¯=â¯26), glandular (nâ¯=â¯14), micropapillary (nâ¯=â¯4), sarcomatoid (nâ¯=â¯4), squamous (nâ¯=â¯3), and plasmacytoid (nâ¯=â¯1) features. Most SmCCs expressed neuroendocrine markers synaptophysin (41/56), chromogranin (26/55), and CD56 (39/41); however, they did not express UC luminal markers CK20 (0/17), GATA3 (1/30), and uroplakin II (1/22). Some SmCCs showed focal expression of CK5/6 (9/25), a marker for the basal molecular subtype. Furthermore, expression of the retinoblastoma 1 (RB1) gene protein was lost in most of the bladder SmCCs (2/23). The patients' survival was significantly associated with cancer stage but did not show a significant difference between mixed and pure SmCCs. Compared with conventional UC at similar stages, SmCC had a worse prognosis only when patients developed metastatic diseases. In conclusion, bladder SmCC is an aggressive disease that is frequently present at an advanced stage. A fraction of SmCCs show a basal molecular subtype, which may underlie its good response to chemotherapy. Inactivation of the RB1 gene may be implicated in the oncogenesis of bladder SmCC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 79, September 2018, Pages 57-65
Journal: Human Pathology - Volume 79, September 2018, Pages 57-65
نویسندگان
Gang MD, PhD, Li MD, Miao MD, PhD, Ashish M. MD, Arlene MD, Colin P. MD, Bogdan MD, PhD, Charles C. MD,