کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8807752 | 1606641 | 2017 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cardiac pathologic findings in 3 unusual cases of sudden cardiac death related to anorexiant drugs
ترجمه فارسی عنوان
یافته های پاتولوژیک قلبی در 3 مورد غیر معمول مرگ ناگهانی قلبی مرتبط با داروهای ضد انعقادی
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کلمات کلیدی
مرگ ناگهانی قلب، داروهای ضد انعقاد، پیگمینترازین، فینیل پروپانولامین، بوپروپیون،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
چکیده انگلیسی
Amphetamine congeners can be prescribed as anorexiant drugs despite their potential adverse effects, including cardiac toxicity. However, the morphologic features of cardiac damage related to protracted use of these compounds are unknown. We provide a detailed description of cardiac autopsy findings in 3 cases of sudden death associated with protracted use of high doses of phendimetrazine and/or phenylpropanolamine or bupropion prescribed as anorexiants, in association with other compounds. The main cardiac findings were similar in all 3 cases: (1) mild-moderate hypertrophy of the left ventricle and/or the septum; (2) myocardial nonischemic scarring (midmural and/or subepicardial) appearing as discrete foci or with a bandlike morphology; (3) mild-moderate intramural small vessel disease in the absence of significant epicardial coronary artery stenosis; and (4) acute/recent inflammatory lesions consistent with toxic myocarditis. In summary, the detailed pathology examination of the heart in these 3 cases revealed myocardial lesions identical to those reported in catecholamine myocardial damage in all their various stages of evolution. In the presence of a clinical history of long-term intake of anorexiants of this category, it is most important at autopsy to recognize and correctly interpret the acute and chronic myocardial lesions of the type herein described because they represent an anatomical substrate for arrhythmic death.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 69, November 2017, Pages 101-109
Journal: Human Pathology - Volume 69, November 2017, Pages 101-109
نویسندگان
Ornella MD, Valentina MD, Alberto MD, Bruna MD, Cira Rosaria Tiziana MD, PhD, Mariarosaria MD, Costantino MD, Joaquin MD, Giulia MD, PhD,