Role of Zc3h12a in enhanced IL-6 production by newborn mononuclear cells in response to lipopolysaccharide

Neonates displayed enhanced IL-6 production after infection. Our study, for the first time, reported a significant decrease in the expression of Zc3h12a in neonates. Thus, Zc3h12a may be a key factor for the aberrant increase in IL-6 after neonate infection.