کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8816406 | 1608475 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We found a significant effect of PRS on positive symptoms at p-threshold (PT) of 0.5 (R2â¯=â¯0.007, pâ¯=â¯0.029, empirical pâ¯=â¯0.029) and negative symptoms at PT of 1e-07 (R2â¯=â¯0.005, pâ¯=â¯0.047, empirical pâ¯=â¯0.048). For models that additionally controlled for neurocognition, best fit PRS predicted positive (p-threshold 0.01, R2â¯=â¯0.007, pâ¯=â¯0.013, empirical pâ¯=â¯0.167) and negative symptoms (p-threshold 0.1, R2â¯=â¯0.012, pâ¯=â¯0.004, empirical pâ¯=â¯0.329). No associations were seen for overall neurocognitive and social cognitive performance tests. Post-hoc analyses revealed that PRS predicted working memory and vigilance performance but did not survive correction. No candidate regions that survived multiple testing corrections were associated with either symptoms or cognitive performance. Our findings point to potentially distinct pathogenic mechanisms for schizophrenia symptoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research: Cognition - Volume 12, June 2018, Pages 11-19
Journal: Schizophrenia Research: Cognition - Volume 12, June 2018, Pages 11-19
نویسندگان
Rose Mary Xavier, Jennifer R. Dungan, Richard S.E. Keefe, Allison Vorderstrasse,