کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8817559 | 1608948 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Grape Seed Procyanidin Extract Reduces Arsenic-Induced Renal Inflammatory Injury in Male Mice
ترجمه فارسی عنوان
عصاره پروپی سینیدین دانه انگور باعث کاهش آسیب التهابی کلیه ناشی از آرسنیک در موش های نر می شود
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
سیاست های بهداشت و سلامت عمومی
چکیده انگلیسی
The aim of the present study is to evaluate the ability and mechanism by which grape seed procyanidin extract (GSPE) relieves arsenic trioxide (As2O3)-induced renal inflammatory injury. Therefore, male Kunming mice were treated with As2O3 and/or GSPE by gavage for 5 weeks. Mice were then sacrificed and inflammatory cytokines of kidneys were examined by ELISA, whereas the expression levels of molecules involved in the nuclear factor (NF)-κB signaling pathway were evaluated by both qRT-PCR and Western blot. Our results indicate that GSPE prevents As2O3-mediated renal inflammatory injury by inhibiting activation of the NF-κB signaling pathway and inflammatory cytokine production, while promoting expression of anti-inflammatory cytokines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedical and Environmental Sciences - Volume 30, Issue 7, July 2017, Pages 535-539
Journal: Biomedical and Environmental Sciences - Volume 30, Issue 7, July 2017, Pages 535-539
نویسندگان
Cheng WANG, Jun LI, Guan Ling SONG, Qiang NIU, Shang Zhi XU, Gang Ling FENG, Hai Xia WANG, Yu LI, Shu Gang LI, Feng LI,