کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8820066 | 1609434 | 2017 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thoracic involvement in IgG4-related disease in a UK-based patient cohort
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کلمات کلیدی
AIPHRAMDTNHSCXRIgG4-RDImmunoglobulin G4-related diseasechest X-ray - اشعه ایکس قفسه سینهIgG4-related disease - بیماری مرتبط با IgG4computed tomography - توموگرافی کامپیوتری یا سی تی اسکن یا مقطعنگاری رایانهایMultidisciplinary team - تیم چند رشته ایNational Health Service - خدمات بهداشت ملیAutoimmune pancreatitis - پانکراتیت اتوایمیون
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی ریوی و تنفسی
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چکیده انگلیسی
IgG4-related disease (IgG4-RD) is a multi-system fibro-inflammatory disorder with classical histopathological findings, often in the context of elevated serum IgG4 levels. The thoracic manifestations of IgG4-RD are numerous and can mimic several common and better known conditions. The objective of this study was to outline the frequency and nature of thoracic involvement in a prospective cohort of IgG4-RD patients who met defined diagnostic criteria. Over 40% of IgG4-RD patients had clinicoradiological and/or histological evidence of thoracic involvement, predominantly mediastinal lymphadenopathy, the majority associated with multi-system disease outside the chest. Thoracic involvement was associated with a higher serum IgG4 level, potentially representing greater disease activity or spread. Our data highlight the diverse nature of thoracic IgG4-RD, and the importance of knowledge and recognition of the condition among respiratory physicians who are likely to encounter this disease entity on an increasing basis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 132, November 2017, Pages 117-121
Journal: Respiratory Medicine - Volume 132, November 2017, Pages 117-121
نویسندگان
John P. Corcoran, Emma L. Culver, Rebekah M. Anstey, Ambika Talwar, Charis D. Manganis, Tamsin N. Cargill, Robert J. Hallifax, Ioannis Psallidas, Najib M. Rahman, Eleanor Barnes,