کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8837632 | 1612882 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Involvement of D1- and D2-like dopamine receptors in the dentate gyrus in the acquisition, expression, and extinction of the morphine-induced conditioned place preference in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Involvement of D1- and D2-like dopamine receptors in the dentate gyrus in the acquisition, expression, and extinction of the morphine-induced conditioned place preference in rats Involvement of D1- and D2-like dopamine receptors in the dentate gyrus in the acquisition, expression, and extinction of the morphine-induced conditioned place preference in rats](/preview/png/8837632.png)
چکیده انگلیسی
In the current study, we investigated the role of intra-dentate gyrus (DG) administration of D1 and/or D2 receptor antagonists on the expression, acquisition, and extinction of morphine-CPP. Cannulae were implanted bilaterally into the DG region in male Wistar rats and CPP was induced by the subcutaneous injection of morphine (5âmg/kg) during a 3-day conditioning phase. Three experimental designs were separately employed in the CPP paradigm during the acquisition, expression and extinction phases, and different doses (0.25, 1, or 4âμg/0.5âμl saline) of SCH23390, as a selective D1-like receptor antagonist, and sulpiride (0.25, 1, or 4âμg/0.5âμl DMSO), as a selective D2-like receptor antagonist, were bilaterally microinjected into the DG region. Conditioning scores and locomotor activities were recorded during the test. Results showed that the injection of the antagonists into the DG region dose-dependently attenuated the acquisition and expression of the morphine-induced CPP and sulpiride revealed prominent behavioral results compared to SCH23390 in both mentioned phases. Moreover, the blockade of D1- and D2-like receptors shortened the extinction phase of the morphine-induced CPP but had no effect on the locomotor activity. We found that the dopamine receptors within the DG region are involved in the acquisition and expression of morphine-CPP and have a critical role in the association between a morphine-paired context and the rewarding proprieties of morphine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 353, 1 November 2018, Pages 185-193
Journal: Behavioural Brain Research - Volume 353, 1 November 2018, Pages 185-193
نویسندگان
Najmeh Katebi, Sharareh Farahimanesh, Zahra Fatahi, Shahram Zarrabian, Abbas Haghparast,