کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8837790 | 1612888 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
5-HT2C receptors in the ventral tegmental area, but not in the arcuate nucleus, mediate the hypophagic and hypolocomotor effects of the selective 5-HT2C receptor agonist AR231630 in rats
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کلمات کلیدی
PFCα-MSHdorsoventralVTAPOMCNPYNACmediolateral - دو طرفهDopamine - دوپامینBehavioral pharmacology - فارماکولوژی رفتاریLocomotor activity - فعالیت locomotorprefrontal cortex - قشر prefrontalArc - قوسPVN - مالیات بر ارزش افزودهfood intake - مصرف غذاventral tegmental area - ناحیه تگمنتوم شکمیNucleus accumbens - هسته accumbensarcuate nucleus - هسته قوسα-Melanocyte stimulating hormone - هورمون تحریک کننده α-ملانوستیReward - پاداشproopiomelanocortin - پروپیوملانوکورتینanteroposterior - پیشاپیشmelanocortin 4 receptor - گیرنده ملانوکورتین 4Neuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 5-HT2C receptors in the ventral tegmental area, but not in the arcuate nucleus, mediate the hypophagic and hypolocomotor effects of the selective 5-HT2C receptor agonist AR231630 in rats 5-HT2C receptors in the ventral tegmental area, but not in the arcuate nucleus, mediate the hypophagic and hypolocomotor effects of the selective 5-HT2C receptor agonist AR231630 in rats](/preview/png/8837790.png)
چکیده انگلیسی
Central serotonin systems have long been associated with the control of feeding behavior and the modulation of behavioral effects of psychostimulants. 5-HT2C receptors are present in hypothalamic centers such as the arcuate nucleus (ARC), controlling homeostatic regulation of food intake, as well as in the ventral tegmental area (VTA), a region involved in motivation aspects in multiple behaviors, including feeding. In the present study, we investigated whether the 5-HT2C receptors control amphetamine-evoked locomotor activity and regulate food consumption. Localized microinjections into the VTA or the ARC were used to assess the effects of a highly selective 5-HT2C receptor agonist, AR231630, on the locomotor stimulant effect of amphetamine as well as on food intake. AR231630 injected into the VTA, but not into the ARC, dose-dependently reduced locomotor activity elicited by amphetamine. Unexpectedly, intra-ARC injection of AR231630 did not reduce food intake even at the dose of 10â¯Î¼g, whereas intra-VTA injection of the same dose of AR231630 did. In addition, we showed that pretreatment with the selective 5-HT2C receptor antagonist SB242084 infused into the VTA partially prevented hypophagia induced by peripheral administration of AR231630. We can conclude that 5-HT2C receptor in the VTA, but not in the ARC, participates in both homeostatic and hedonic food intake and brain reward function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 347, 16 July 2018, Pages 234-241
Journal: Behavioural Brain Research - Volume 347, 16 July 2018, Pages 234-241
نویسندگان
Sina Faton, Jean-Pol Tassin, Flore Duranton, Didier Bagnol, Anne-Dominique Lajoix,