کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8837790 | 1612888 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
5-HT2C receptors in the ventral tegmental area, but not in the arcuate nucleus, mediate the hypophagic and hypolocomotor effects of the selective 5-HT2C receptor agonist AR231630 in rats
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کلمات کلیدی
PFCα-MSHdorsoventralVTAPOMCNPYNACmediolateral - دو طرفهDopamine - دوپامینBehavioral pharmacology - فارماکولوژی رفتاریLocomotor activity - فعالیت locomotorprefrontal cortex - قشر prefrontalArc - قوسPVN - مالیات بر ارزش افزودهfood intake - مصرف غذاventral tegmental area - ناحیه تگمنتوم شکمیNucleus accumbens - هسته accumbensarcuate nucleus - هسته قوسα-Melanocyte stimulating hormone - هورمون تحریک کننده α-ملانوستیReward - پاداشproopiomelanocortin - پروپیوملانوکورتینanteroposterior - پیشاپیشmelanocortin 4 receptor - گیرنده ملانوکورتین 4Neuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Central serotonin systems have long been associated with the control of feeding behavior and the modulation of behavioral effects of psychostimulants. 5-HT2C receptors are present in hypothalamic centers such as the arcuate nucleus (ARC), controlling homeostatic regulation of food intake, as well as in the ventral tegmental area (VTA), a region involved in motivation aspects in multiple behaviors, including feeding. In the present study, we investigated whether the 5-HT2C receptors control amphetamine-evoked locomotor activity and regulate food consumption. Localized microinjections into the VTA or the ARC were used to assess the effects of a highly selective 5-HT2C receptor agonist, AR231630, on the locomotor stimulant effect of amphetamine as well as on food intake. AR231630 injected into the VTA, but not into the ARC, dose-dependently reduced locomotor activity elicited by amphetamine. Unexpectedly, intra-ARC injection of AR231630 did not reduce food intake even at the dose of 10â¯Î¼g, whereas intra-VTA injection of the same dose of AR231630 did. In addition, we showed that pretreatment with the selective 5-HT2C receptor antagonist SB242084 infused into the VTA partially prevented hypophagia induced by peripheral administration of AR231630. We can conclude that 5-HT2C receptor in the VTA, but not in the ARC, participates in both homeostatic and hedonic food intake and brain reward function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 347, 16 July 2018, Pages 234-241
Journal: Behavioural Brain Research - Volume 347, 16 July 2018, Pages 234-241
نویسندگان
Sina Faton, Jean-Pol Tassin, Flore Duranton, Didier Bagnol, Anne-Dominique Lajoix,