کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8837833 | 1612890 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Baclofen blocks the acquisition and expression of mitragynine-induced conditioned place preference in rats
ترجمه فارسی عنوان
باکلوفن جذب و بیان گرایش موضعی تهویه شده توسط میترگینین را در موش صحرایی متوقف می کند
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کلمات کلیدی
میترگینین، باکوفن، اکتساب، حاکمیت، اصطلاح، ترجیح محل مواجه،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Mitragynine is the major alkaloid found in the leaves of M. speciosa Korth (Rubiaceae), a plant that is native to Southeast Asia. This compound has been used, either traditionally or recreationally, due to its psychostimulant and opioid-like effects. Recently, mitragynine has been shown to exert conditioned place preference (CPP), indicating the rewarding and motivational properties of M. speciosa. Here, the involvement of GABAB receptors in mediating mitragynine reward is studied using a CPP paradigm in rats. First, we examined the effects of GABAB receptor agonist baclofen (1.25, 2.5 and 5â¯mg/kg) on the acquisition of mitragynine (10â¯mg/kg)-induced CPP. Second, the involvement of GABAB receptors in the expression of mitragynine-induced CPP was tested. We found that the acquisition of mitragynine-induced CPP could be blocked by higher doses (2.5 and 5â¯mg/kg) of baclofen. Baclofen at a high dose inhibited locomotor activity and caused a CPP. Furthermore, we found that baclofen (2.5 and 5â¯mg/kg) also blocked the expression of mitragynine-induced CPP. These findings suggest that both, the acquisition and expression of mitragynine's reinforcing properties is controlled by the GABAB receptor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 345, 1 June 2018, Pages 65-71
Journal: Behavioural Brain Research - Volume 345, 1 June 2018, Pages 65-71
نویسندگان
Nurul H.M. Yusoff, Sharif M. Mansor, Christian P. Müller, Zurina Hassan,