کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8837842 | 1612889 | 2018 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glutamine/glutamate (Glx) concentration in prefrontal cortex predicts reversal learning performance in the marmoset
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Glutamine/glutamate (Glx) concentration in prefrontal cortex predicts reversal learning performance in the marmoset Glutamine/glutamate (Glx) concentration in prefrontal cortex predicts reversal learning performance in the marmoset](/preview/png/8837842.png)
چکیده انگلیسی
This study used Magnetic Resonance Spectroscopy (MRS) to identify potential neurometabolitic markers of cognitive performance in male (nâ¯=â¯7) and female (nâ¯=â¯8) middle-aged (â¼5 years old) common marmosets (Callithrix jacchus). Anesthetized marmosets were scanned with a 4.7â¯T/40â¯cm horizontal magnet equipped with 450â¯mT/m magnetic field gradients and a 20â¯G/cm magnetic field gradient insert, within 3 months of completing the CANTAB serial Reversal Learning task. Neurometabolite concentrations of N-Acetyl Asparate, Myo-Inositol, Choline, Phosphocreatineâ¯+â¯creatine, Glutamate and Glutamine were acquired from a 3â¯mm3 voxel positioned in the Prefrontal Cortex (PFC). Males acquired the reversals (but not simple discriminations) faster than the females. Higher PFC Glx (glutamateâ¯+â¯glutamine) concentration was associated with faster acquisition of the reversals. Interestingly, the correlation between cognitive performance and Glx was significant in males, but not in females. These results suggest that MRS is a useful tool to identify biochemical markers of cognitive performance in the healthy nonhuman primate brain and that biological sex modulates the relationship between neurochemical composition and cognition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 346, 2 July 2018, Pages 11-15
Journal: Behavioural Brain Research - Volume 346, 2 July 2018, Pages 11-15
نویسندگان
Agnès Lacreuse, Constance M. Moore, Matthew LaClair, Laurellee Payne, Jean A. King,