کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8838230 | 1613091 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Biospecimen collection in the Adolescent Brain Cognitive Development (ABCD) study - of hair samples, shed deciduous (baby) teeth, and body fluids - will serve dual functions of screening for study eligibility, and providing measures of biological processes thought to predict or correlate with key study outcomes on brain and cognitive development. Biosamples are being collected annually to screen for recency of drug use prior to the neuroimaging or cognitive testing visit, and to store for the following future studies: (1) on the effects of exposure to illicit and recreational drugs (including alcohol and nicotine); (2) of pubertal hormones on brain and cognitive developmental trajectories; (3) on the contribution of genomics and epigenomics to child and adolescent development and behavioral outcomes; and (4) with pre- and post-natal exposure to environmental neurotoxicants and drugs of abuse measured from novel tooth analyses. The present manuscript describes the rationales for inclusion and selection of the specific biospecimens, methodological considerations for each measure, future plans for assessment of biospecimens during follow-up visits, and preliminary ABCD data to illustrate methodological considerations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Cognitive Neuroscience - Volume 32, August 2018, Pages 97-106
Journal: Developmental Cognitive Neuroscience - Volume 32, August 2018, Pages 97-106
نویسندگان
Kristina A. Uban, Megan K. Horton, Joanna Jacobus, Charles Heyser, Wesley K. Thompson, Susan F. Tapert, Pamela A.F. Madden, Elizabeth R. Sowell, the Adolescent Brain Cognitive Development Study the Adolescent Brain Cognitive Development Study,