کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8838800 | 1613215 | 2018 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduction of amyloid beta by Aβ3-10-KLH vaccine also decreases tau pathology in 3ÃTg-AD mice
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive amyloid-β (Aβ) accumulation, neurofibrillary tangles (NFTs) formation and synaptic alterations. Active immunotherapy is regarded as one of the most promising strategies for AD prevention and treatment. In this research, we used APPswe/PS1M146âV/TauP301âL triple transgenic (3ÃTg-AD) mice, in which the pathological changes are the most similar to those in AD patients. The Aβ 3-10 -keyhole limpet haemocyanin (KLH) vaccine was administered to mice at 1 month, and no AD-associated changes were detected at that time. The vaccine effectively mitigated AD-like pathology and cognitive dysfunction in the 3ÃTg-AD mice. Both soluble and insoluble Aβ and tau protein in the brain tissues of the 3ÃTg-AD mice were significantly decreased after the administration of Aβ 3-10 -KLH. In addition, the level of phosphorylated tau also decreased following removal of the Aβ pathological changes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 142, September 2018, Pages 233-240
Journal: Brain Research Bulletin - Volume 142, September 2018, Pages 233-240
نویسندگان
Hui-Yi Zhang, Kun Zhu, Yuan Meng, Li Ding, Jin-Chun Wang, Wen-Chao Yin, Yi Yan, Yun-Peng Cao,