کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8838925 | 1613218 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Opioid and α2 adrenergic mechanisms are activated by GABA agonists in the lateral parabrachial nucleus to induce sodium intake
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The activation of GABA, opioid or α2 adrenergic mechanisms in the lateral parabrachial nucleus (LPBN) facilitates hypertonic NaCl intake in rats. In the present study, we combined opioid or α2 adrenergic antagonists with GABA agonists into the LPBN in order to investigate if NaCl intake caused by GABAergic activation in normohydrated rats depends on opioid or α2-adrenergic mechanisms in this area. Male Holtzman rats with stainless steel cannulas implanted bilaterally in the LPBN were used. Bilateral injections of muscimol or baclofen (GABAA and GABAB agonists, respectively, 0.5â¯nmol/0.2â¯Î¼l) into the LPBN induced strong ingestion of 0.3â¯M NaCl (45.8â¯Â±â¯7.3 and 21.8â¯Â±â¯4.8â¯ml/240â¯min, respectively) and water intake (22.7â¯Â±â¯3.4 and 6.6â¯Â±â¯2.5â¯ml/240â¯min, respectively). Naloxone (opioid antagonist, 150â¯nmol/0.2â¯Î¼l) into the LPBN abolished 0.3â¯M NaCl and water intake to muscimol (2.0â¯Â±â¯0.6 and 0.9â¯Â±â¯0.2â¯ml/240â¯min, respectively) or baclofen (2.3â¯Â±â¯1.1 and 0.8â¯Â±â¯0.4â¯ml/240â¯min, respectively). RX 821002 (α2 adrenoceptor antagonist, 10â¯nmol/0.2â¯Î¼l) into the LPBN reduced 0.3â¯M NaCl intake induced by the injections of muscimol or baclofen (26.6â¯Â±â¯8.0 and 10.1â¯Â±â¯4.9â¯ml/240â¯min, respectively). RX 821002 reduced water intake induced by muscimol (7.7â¯Â±â¯2.9â¯ml/240â¯min), not by baclofen. The results suggest that sodium intake caused by gabaergic activation in the LPBN in normohydrated rats is totally dependent on the activation of opioid mechanisms and partially dependent on the activation of α2 adrenergic mechanisms in the LPBN.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 139, May 2018, Pages 174-181
Journal: Brain Research Bulletin - Volume 139, May 2018, Pages 174-181
نویسندگان
Lisandra B. De Oliveira, Carina A.F. Andrade, Laurival A. Jr, Débora S.A. Colombari, José V. Menani,