کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8839628 1613745 2018 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The use of focused ultrasound for the treatment of cutaneous allodynia associated with chronic migraine
ترجمه فارسی عنوان
استفاده از سونوگرافی متمرکز برای درمان آلدوینیا پوستی همراه با میگرن مزمن
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Chronic migraines (CM) are the third most common disease and are refractory to medical treatment in 15% of patients. Currently, temporary relief is achieved with steroid blocks or pulsed radiofrequency ablation, which have short-term benefits. Our project aims to develop a non-invasive treatment for medically refractory chronic migraine, which does not require a permanent implant. This project investigates the safety and effectiveness of pulsed focused ultrasound (FUS) in a validated rodent headache model of cutaneous allodynia associated with chronic migraine (CM) as compared to sumatriptan and ablative lesioning. We demonstrate a significant reduction in mechanical thresholds as measured through Von Frey filaments in CM in the forepaw and periorbital region (p < 0.001). Sumatriptan and pulsed FUS both significantly improve thresholds at day 3 after treatment in the periorbital region. Ablative lesioning has no effect. This study provides initial evidence that FUS may provide an important therapeutic option for patients suffering from CM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1699, 15 November 2018, Pages 135-141
نویسندگان
, , , , , , , , , , , , , , , ,