کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839659 | 1613746 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of hippocampal low-frequency stimulation on GABAA R α1, ICER and BNDF expression level in brain tissues of amygdala-kindled drug-resistant temporal lobe epileptic rats
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کلمات کلیدی
CREBaverage optical densityp-CREBElectroencephalogramsAEDsADTIODPHTHLSBNDFNRCDRCCREICERDBSDSCTherapeutic effect - اثر درمانیSprague–Dawley - اسپراگ داولیγ-aminobutyric acid - اسید γ-آمینوبوتیریکstatus epilepticus - بحران صرعی یا صرع پایدارdeep brain stimulation - تحریک عمقی مغزintegrated optical density - تراکم نوری یکپارچهAntiepileptic medications - داروهای ضد صرعInducible cAMP early repressor - سرکوب کننده اولیه cAMP قابل انعطاف استdrug-resistant epilepsy - صرع مقاوم در برابر داروcAMP-responsive element - عنصر پاسخگو cAMPbrain-derived neurotrophic factors - فاکتورهای نوروپاتی ناشی از مغزPhenobarbital - فنوباربیتالEEG - نوار مغزیcAMP-response element binding protein - پروتئین اتصال دهنده عنصر cAMPGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study investigated the therapeutic effect of hippocampal low-frequency stimulation (Hip-LFS) and its influence on the type A γ-aminobutyric acid receptor α1 subunit (GABAA R α1 subunit), inducible cAMP early repressor (ICER) and brain-derived neurotrophic factors (BNDF). The model of epilepsy was induced by chronic electrical stimulation in amygdala. Drug-resistant and drug-sensitive epileptic rats were selected by testing their seizure response to phenytoin and phenobarbital. The changes of GABAA R α1 subunit, ICER and BDNF expression were detected via immunohistochemistry and western blot. The expression levels of ICER and BDNF were increased remarkably but the GABAA R α1 subunit decreased significantly in the drug-resistant epileptic rats. However, the expression levels of ICER, BDNF were decreased and the expression of the GABAA R α1 subunit increased significantly in the drug-resistant epileptic rats after two weeks of Hip-LFS. Meanwhile, the seizure degree was reduced and the electroencephalograms were improved. The present study demonstrated that increased ICER and BDNF might be associated with the development of drug-resistance. The effect of Hip-LFS in the treatment of drug-resistant epileptic rats might be associated with increasing the levels of the ICER and the BDNF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1698, 1 November 2018, Pages 195-203
Journal: Brain Research - Volume 1698, 1 November 2018, Pages 195-203
نویسندگان
Kaya Xu, Zhaoyang Liu, Likun Wang, Guofeng Wu, Tao Liu,