کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839683 | 1613748 | 2018 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Postconditioning with sevoflurane ameliorates spatial learning and memory deficit via attenuating endoplasmic reticulum stress induced neuron apoptosis in a rat model of hemorrhage shock and resuscitation
ترجمه فارسی عنوان
تعویض پس از تزریق با سووفلوران، کاهش یادگیری مکانی و کسری حافظه را کاهش می دهد از طریق کاهش ضایعه آپوپتوزیون نورون ناشی از استرس تناسلی اندوپلاسمی در یک مدل موش های شوک خونریزی و احیاء
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کلمات کلیدی
شوک خونریزی و احیا، یادگیری فضایی و حافظه، پس از تهیه سووفلوران، استرس تناسلی اندوپلاسمی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Hemorrhage shock could initiate endoplasmic reticulum stress (ERS) and then induce neuronal apoptosis. The aim of this study was to investigate whether sevoflurane postconditioning could attenuate brain injury via suppressing apoptosis induced by ERS. Seventy male rats were randomized into five groups: sham, shock, low concentration (sevo1, 1.2%), middle concentration (sevo2, 2.4%) and high concentration (sevo3, 3.6%) of sevoflurane postconditioning. Hemorrhage shock was induced by removing 40% of the total blood volume during an interval of 30â¯min. 1â¯h after the completion of bleeding, the animals were reinfused with shed blood during the ensuing 30â¯min. The spatial learning and memory ability of rats were measured by Morris water maze (MWM) test three days after the operation. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) positive cells in the hippocampus CA1 region were assessed after the MWM test. The expression of C/EBP-homologousprotein (CHOP) and glucose-regulated protein 78 (GRP78) in the hippocampus were measured at 24â¯h after reperfusion. We found that sevoflurane postconditioning with the concentrations of 2.4% and 3.6% significantly ameliorated the spatial learning and memory ability, decreased the TUNEL-positive cells, and reduced the GRP78 and CHOP expression compared with the shock group. These results suggested that sevoflurane postconditioning with the concentrations of 2.4% and 3.6% could ameliorate spatial learning and memory deficit after hemorrhage shock and resuscitation injury via suppressing apoptosis induced by ERS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1696, 1 October 2018, Pages 49-55
Journal: Brain Research - Volume 1696, 1 October 2018, Pages 49-55
نویسندگان
Xianwen Hu, Jingxian Wang, Li Zhang, Qiquan Zhang, Xiaowen Duan, Ye Zhang,