کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839856 | 1613760 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activation of the subthalamic nucleus suppressed by high frequency stimulation: A c-Fos immunohistochemical study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Deep brain stimulation applied at high frequency (HFS) to the subthalamic nucleus (STN) is used to ameliorate the symptoms of Parkinson's disease. The mechanism by which this is achieved remains controversial. In particular, it is uncertain whether HFS has a suppressive or excitatory action locally within the STN. Brief exposure of rats to ether anesthesia evokes pathological burst firing and associated expression of the immediate early gene c-Fos in STN neurons. We used this ether model of STN activation to test the effect of a range of HFS parameters on c-Fos expression evoked by the anesthetic. The elevated baseline of c-Fos expression afforded the possibility of detecting further excitatory, or suppressive effects of STN HFS. Four HFS protocols were examined; 130, 200 and 260â¯Hz with 60â¯Âµs, and 130â¯Hz with 90â¯Âµs pulse width (HFS intensity:150-300â¯ÂµA). All HFS protocols were applied for 20â¯min while the animals were exposed to ether. Ether-evoked expression of c-Fos immunoreactivity was suppressed by HFS at 200 and 260â¯Hz with a pulse width of 60â¯Âµs, and by 130â¯Hz when the pulse width was increased to 90â¯Âµs. HFS at 130â¯Hz with the 60â¯Âµs pulse width had no significant effect and HFS alone caused negligible c-Fos expression in the STN. These findings suggest that HFS of the STN causes significant suppression of evoked neuronal activity. It remains to be determined whether this locally suppressive property of HFS is associated with the efficacy of STN deep brain stimulation to relieve the symptoms of Parkinson's disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1685, 15 April 2018, Pages 42-50
Journal: Brain Research - Volume 1685, 15 April 2018, Pages 42-50
نویسندگان
Safa Shehab, Crystal D'souza, Milos Ljubisavljevic, Peter Redgrave,