کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839857 | 1613760 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Indices of repetitive behaviour are correlated with patterns of intrinsic functional connectivity in youth with autism spectrum disorder
ترجمه فارسی عنوان
شاخص های رفتار تکراری با الگوهای همبستگی عملکردی درونی در جوانان مبتلا به اختلال طیف اوتیسم ارتباط دارد
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کلمات کلیدی
اختلال طیف اوتیسم، رفتار تکراری، تصویربرداری رزونانس مغناطیسی عملکرد حالت حالت اتصال عملکردی ذاتی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
The purpose of the current study was to examine how repetitive behaviour in Autism Spectrum Disorder (ASD) is related to intrinsic functional connectivity patterns in a number of large-scale, neural networks. Resting-state fMRI scans from thirty subjects with ASD and thirty-two age-matched, typically developing control subjects were analysed. Seed-to-voxel and ROI-to-ROI functional connectivity analyses were used to examine resting-state connectivity in a number of cortical and subcortical neural networks. Bivariate correlation analysis was performed to examine the relationship between repetitive behaviour scores from the Repetitive Behaviour Scale - Revised and intrinsic functional connectivity in ASD subjects. Compared to control subjects, ASD subjects displayed marked over-connectivity of the thalamus with several cortical sensory processing areas, as well as over-connectivity of the basal ganglia with somatosensory and motor cortices. Within the ASD group, significant correlations were found between functional connectivity patterns and total RBS-R scores as well as one principal component analysis-derived score from the RBS-R. These results suggest that thalamocortical resting-state connectivity is altered in individuals with ASD, and that resting-state functional connectivity is associated with ASD symptomatology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1685, 15 April 2018, Pages 79-90
Journal: Brain Research - Volume 1685, 15 April 2018, Pages 79-90
نویسندگان
J.M. Traynor, K.A.R. Doyle-Thomas, L.C. Hanford, N.E. Foster, A. Tryfon, K.L. Hyde, E. Anagnostou, A.C. Evans, L. Zwaigenbaum, G.B.C. Hall, NeuroDevNet ASD Imaging Group NeuroDevNet ASD Imaging Group,