کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8840915 | 1614702 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dysfunctional Limbic Circuitry Underlying Freezing of Gait in Parkinson's Disease
ترجمه فارسی عنوان
انسداد مجاری تناسلی در مبتلایان به بیماری پارکینسون
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کلمات کلیدی
FDRrsfMRIFPNRSFCPIGDBOLDResting-state functional MRI - MRI عملکرد حالت آرامROIs - ROI هاAmygdala - آمیگدال، بادامهResting-state functional connectivity - اتصال حالت عملکرد حالت حالت استراحتGait disorders - اختلالات خلقیAnxiety - اضطرابFunctional MRI - افامآرآی یا تصویرسازی تشدید مغناطیسی کارکردیParkinson’s disease - بیماری پارکینسونblood oxygen level dependent - سطح اکسیژن خون وابسته استregions of interests - مناطق منافعFog - مهfalse discovery rate - میزان کشف کاذبPutamen - پوسته، پوتامنFreezing of gait - یخ زدن راه رفتن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Freezing of gait (FOG) is a poorly understood symptom affecting many patients with Parkinson's disease (PD). Despite growing evidence of a behavioral link between anxiety, attention and FOG in PD, no research to date has investigated the neural mechanisms that might explain this relationship. The present study therefore examined resting-state MRI functional connectivity between the amygdala, striatum and frontoparietal attentional control network in PD patients with (freezers: nâ¯=â¯19) and without FOG (non-freezers: nâ¯=â¯21) in the dopaminergic 'off' state. Functional connectivity was subsequently correlated with an objective measure of FOG severity and a subjective scale of affective disorder within each group. Connectivity between the right amygdala and right putamen was significantly increased in freezers compared to non-freezers (pâ¯<â¯0.01). Furthermore, freezers showed increased anti-coupling between the frontoparietal network and left amygdala (pâ¯=â¯0.011), but reduced anti-coupling between this network and the right putamen (pâ¯=â¯0.027) as compared to non-freezers. Key functional connections between the amygdala, putamen and frontoparietal network were significantly associated with FOG severity and a fear of falling. This study provides the first evidence that dysfunctional fronto-striato-limbic processes may underpin the link between anxiety and FOG in PD. It is proposed that freezers have heightened striato-limbic load and reduced top-down attentional control at rest, which when further challenged by the parallel processing demands of walking may precipitate FOG.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 374, 15 March 2018, Pages 119-132
Journal: Neuroscience - Volume 374, 15 March 2018, Pages 119-132
نویسندگان
Moran Gilat, Kaylena A. Ehgoetz Martens, Oscar Miranda-DomÃnguez, Ishu Arpan, James M. Shine, Martina Mancini, Damien A. Fair, Simon J.G. Lewis, Fay B. Horak,