کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8842159 | 1615259 | 2017 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes in cortical excitability during paired associative stimulation in Parkinson's disease patients and healthy subjects
ترجمه فارسی عنوان
تغییرات تحریک پذیری قشر در تحریک وابسته به زوج در بیماران مبتلا به بیماری پارکینسون و افراد سالم
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کلمات کلیدی
تحریک وابسته به انگشتی، تحریک مغناطیسی ترانس مغناطیسی، تحریک پذیری قشر، مهار نفس، بیماری پارکینسون، ادغام حسی-موتور
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Paired associative stimulation (PAS) combines repetitive peripheral nerve stimulation with motor cortex (M1) transcranial magnetic stimulation (TMS), to induce plastic-like changes of cortical excitability. While much attention has been dedicated to post-PAS effects little is known about processes during PAS. We compared the time-course of changes in M1 excitability during standard facilitatory PAS intervention among patients with Parkinson's disease (PD), known to have diminished post-PAS response, and healthy subjects. Compared to baseline pre-PAS MEPs, conditioned MEPs during PAS decreased significantly in both groups. The decrease was significantly larger in healthy subjects than in PD patients, regardless whether patients were drug-naïve or not. Although post-PAS excitability increase was also larger in healthy subjects than in PD patients, there was no significant correlation between the two phenomena, i.e. the extent of MEP decrease during PAS and the extent of the post-PAS excitability increase. The results highlight an apparent physiological paradox that repetitive application of an inhibitory stimulation pattern leads to subsequent prolonged facilitation, thus broadening the understanding of the phenomenology of PAS response. Results also suggest that in PD cortical circuits involved in conveying inhibition during PAS, are impaired at the clinical onset of the disease and are not influenced by subsequent PD treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 124, November 2017, Pages 51-56
Journal: Neuroscience Research - Volume 124, November 2017, Pages 51-56
نویسندگان
Aleksandra KaÄar, Sladjan D. MilanoviÄ, SaÅ¡a R. FilipoviÄ, MiloÅ¡ R. LjubisavljeviÄ,