کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8876606 1623757 2018 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A mathematical approach to effects of CTLs on cancer virotherapy in the second injection of virus
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
A mathematical approach to effects of CTLs on cancer virotherapy in the second injection of virus
چکیده انگلیسی
This paper proposes a planar delay differential equation for cancer virotherapy. The model simulates the situation in which an oncolytic virus is injected for the second time, and the immune system suppresses the viral infection with a time delay. Our purpose is to provide theoretical conditions so that the therapy can be continued successfully. With the help of the characteristic equation, we examine the singularities and their local stability. Hopf bifurcation is also investigated around the endemic singularity. It is shown that there is a sequence of Hopf bifurcations, but the Hopf cycles do not persist continuously between the two sequential bifurcations. Finally, we see that virotherapy can be conducted successfully by controlling the delay parameter.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 453, 14 September 2018, Pages 78-87
نویسندگان
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