کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8876668 1623761 2018 30 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Using high resolution X-ray computed tomography to create an image based model of a lymph node
ترجمه فارسی عنوان
با استفاده از توموگرافی کامپیوتری با اشعه ایکس با وضوح بالا برای ایجاد یک مدل مبتنی بر تصویر از گره
کلمات کلیدی
سیستم لنفاوی، مدلسازی مبتنی بر تصویر، رسانه های متخلخل،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی
Lymph nodes are an important part of the immune system. They filter the lymphatic fluid as it is transported from the tissues before being returned to the blood stream. The fluid flow through the nodes influences the behaviour of the immune cells that gather within the nodes and the structure of the node itself. Measuring the fluid flow in lymph nodes experimentally is challenging due to their small size and fragility. In this paper, we present high resolution X-ray computed tomography images of a murine lymph node. The impact of the resulting visualized structures on fluid transport are investigated using an image based model. The high contrast between different structures within the lymph node provided by phase contrast X-ray computed tomography reconstruction results in images that, when related to the permeability of the lymph node tissue, suggest an increased fluid velocity through the interstitial channels in the lymph node tissue. Fluid taking a direct path from the afferent to the efferent lymphatic vessel, through the centre of the node, moved faster than the fluid that flowed around the periphery of the lymph node. This is a possible mechanism for particles being moved into the cortex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 449, 14 July 2018, Pages 73-82
نویسندگان
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