In vivo study on analgesic, gastrointestinal tract (GIT) motility, and anti-termite potential of methanolic extract of Sarcococca saligna (D. Don) Muell. fruits

The current paper summarizes the evaluation of the alcoholic extract of Sarcococca saligna (D. Don) Mull. fruits for acute toxicity, analgesic, GIT motility modulation, and anti-termite properties. The extract was evaluated for analgesic activity using acetic acid-induced writhing model while charcoal meal model was adopted for GIT motility estimation in mice. The fruit extract exhibited significant analgesic and GIT motility potential at 700, 1000 mg/kg i.p. in comparison to standard drug (Diclofenac sodium). The extract also showed good anti-termite activity. The extract was also evaluated for toxicological effects which showed that the fruit extract is safe for the consumption of mice at 1000 mg/kg i.p.