کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8883692 | 1625905 | 2018 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stage-dependent effects of chlorpyrifos on medaka (Oryzias latipes) swimming behavior using a miniaturized swim flume
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کلمات کلیدی
w.w.DPHCPFMTBEDMSO - DMSOGC–MS - GC-MSELS - آنهاAChE - آهیOrganophosphate - ارگانوفسفاتAcetylcholinesterase - استیل کولین استرازDimethyl sulfoxide - دیمتیل سولفواکسیدSwimming behavior - رفتار شناForced swimming - شنا کردن اجباریgas chromatography–mass spectrometry - طیف سنجی جرم کروماتوگرافی گازMethanol - متانولmethyl tert-Butyl ether - متیل ترتل-بوتیل اترearly life stages - مراحل اولیه زندگیMeOH - مونwet weight - وزن مرطوبChlorpyrifos - کلرپیریفوس
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
By considering chlorpyrifos (CPF), an organophosphorus pesticide with known mechanisms of action that affect neurobehavioral development, we assessed the validity and sensitivity of a miniaturized swim flume by investigating the effects of the insecticide on swimming behavior in medaka (Oryzias latipes) fish growing stages. Medaka in three developmental periods, namely 0, 20 and 40â¯day-old post-hatch (i.e. time points 0, 20 and 40, respectively), were exposed to CPF (12.5, 25, 50 and 100â¯Î¼g/L) for 48â¯h under semi-static conditions. The CPF half-lives during exposures were evaluated and the swimming patterns in a flume section (arena) were presented on two-dimensional gradient maps of forced movement of fish against water current. A comparative numerical analysis of fish residence times between each time point control and the corresponding CPF groups was performed by dividing arenas into 15 proportional areas. The time point 0 control group gradient map showed a noticeably different swim pattern from those of the â¥12.5â¯Î¼g CPF/L groups, which was statistically supported by the differences for residence times seen in â¥12 corresponding areas. The control group gradient maps for time points 20 and 40 differed from those of the respective â¥12.5â¯Î¼g CPF/L groups. The comparative analysis of the residence times in the corresponding 15 areas revealed differences in â¥5 areas for time point 20 and in â¥3 areas for time point 40. The integrative analysis of the gradient maps and the numerical statistics revealed stage-specific effects and a concentration-response relationship between CPF and alterations on forced medaka swimming despite the dissipation of CPF from the water column. These results indicate the validity of the miniaturized swim flume toward a more environmentally realistic scenario for the evaluation of neurodevelopmental and behavioral toxicity in small fish models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquatic Toxicology - Volume 200, July 2018, Pages 37-49
Journal: Aquatic Toxicology - Volume 200, July 2018, Pages 37-49
نویسندگان
Salvador Sastre, Carlos Fernández Torija, Irene Atiénzar Pertusa, Eulalia MarÃa Beltrán, MarÃa Victoria Pablos, Miguel González-Doncel,