کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8883954 | 1625912 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thyroid disrupting effects of halogenated and next generation chemicals on the swim bladder development of zebrafish
ترجمه فارسی عنوان
اثرات مخرب تیروئید از مواد شیمیایی هالوژن و نسل بعدی بر روی رشد مثانه ماهیان دریایی
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کلمات کلیدی
فلوئورینید، ماهی، انفجار شعله شنا کردن مثانه، سطوح سرب
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
چکیده انگلیسی
Endocrine disrupting chemicals (EDCs) can alter thyroid function and adversely affect growth and development. Halogenated compounds, such as perfluorinated chemicals commonly used in food packaging, and brominated flame retardants used in a broad range of products from clothing to electronics, can act as thyroid disruptors. Due to the adverse effects of these compounds, there is a need for the development of safer next generation chemicals. The objective of this study was to test the thyroid disruption potential of old use and next generation halogenated chemicals. Zebrafish embryos were exposed to three old use compounds, perfluorooctanoic acid (PFOA), tetrabromobisphenol A (TBBPA) and tris (1,3-dichloro-2-propyl) phosphate (TDCPP) and two next generation chemicals, 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxdie (DOPO) and perfluorobutyric acid (PFBA). Sub-chronic (0-6Â days post fertilization (dpf)) and chronic (0-28Â dpf) exposures were conducted at 1% of the concentration known to kill 50% (LC50) of the population. Changes in the surface area of the swim bladder as well as in expression levels of genes involved in the thyroid control of swim bladder inflation were measured. At 6Â dpf, zebrafish exposed to all halogenated chemicals, both old use and next generation, had smaller posterior swim bladder and increased expression in the gene encoding thyroid peroxidase, tpo and the genes encoding two swim bladder surfactant proteins, sp-a and sp-c. These results mirrored the effects of thyroid hormone-exposed positive controls. Fish exposed to a TPO inhibitor (methimazole, MMI) had a decrease in tpo expression levels at 28Â dpf. Effects on the anterior swim bladder at 28Â dpf, after exposure to MMI as well as both old and new halogenated chemicals, were the same, i.e., absence of SB in â¼50% of fish, which were also of smaller body size. Overall, our results suggest thyroid disruption by the halogenated compounds tested via the swim bladder surfactant system. However, with the exception of TBBPA and TDCPP, the concentrations tested (â¼5-137Â ppm) are not likely to be found in the environment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquatic Toxicology - Volume 193, December 2017, Pages 228-235
Journal: Aquatic Toxicology - Volume 193, December 2017, Pages 228-235
نویسندگان
Amy Godfrey, Blair Hooser, Ahmed Abdelmoneim, Katharine A. Horzmann, Jennifer L. Freemanc, Maria S. Sepúlveda,