کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8926448 | 1643680 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Traitement conservateur des hyperplasies atypiques et cancers de l'endomètre et préservation de la fertilité
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کلمات کلیدی
oncofertility - بیماری زودرسPréservation de la fertilité - حفاظت از باروریfertility preservation - حفظ باروریTraitement conservateur - درمان محافظه کارانهYoung women - زنان جوانEndometrial cancer - سرطان آندومترCancer de l’endomètre - سرطان آندومترConservative management - مدیریت محافظه کارAtypical endometrial hyperplasia - هیپرپلازی اندومتری غیرطبیعی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
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چکیده انگلیسی
The fertility sparing management of endometrial cancer and atypical hyperplasia concern women in childbearing age with stage 1, grade 1, endometrioid adenocarcinoma confined to endometrium or atypical hyperplasia (simple or complex). These pathologies affecting more frequently postmenopausal women, the number of people involved is relatively low. The main risk factor is hyperestrogenism and these patients often present a history of infertility with a desire for pregnancy. The recommendations for this conservative management are scarce and unclear. The national observatory in the gynecology and obstetrics department of Bichat hospital gives expert advice to help doctors and patients concerned. We present a type of conservative management based on the expertise of the national observatory. Rigorous pre-therapeutic assessment must first be made to avoid missing a more advanced lesion. Hormone therapy is then started to obtain complete remission. In case of remission, fast achieving pregnancy is advised, and the use of assisted reproductive therapy is possible if necessary. Monitoring by hysteroscopy and histological examination is essential during the treatment. Hysterectomy is the last time the conservative management. It is motivated by the risk of recurrence and progression. The probability of remission after conservative treatment is estimated at 78.0Â % at 12Â months, the probability of recurrence at 29.2Â % at 24Â months, and the risk of progression at 15Â % (stage 1A with myometrial invasion or more on the hysterectomy specimen). In terms of fertility, 32Â % of women get at least one pregnancy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynécologie Obstétrique Fertilité & Sénologie - Volume 45, Issue 2, February 2017, Pages 112-118
Journal: Gynécologie Obstétrique Fertilité & Sénologie - Volume 45, Issue 2, February 2017, Pages 112-118
نویسندگان
C. Gonthier, A. Trefoux-Bourdet, D. Luton, M. Koskas,