کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8943928 | 1645217 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydroxyurea-induced onychomadesis in a dog with chronic myeloid leukemia: A case report
ترجمه فارسی عنوان
آنیکومادیس ناشی از هیدروکسی اوره در سگ مبتلا به لوسمی میلوئید مزمن: یک گزارش مورد
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
سگ هیدروکسی کربامید، آنیکولیز،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
A 12-year-old Rottweiler dog was presented with a history of prostration, weight loss and hyporexia for six months. Based on complete blood tests (hematological and biochemical analyses), bone marrow examination and imaging analysis, a diagnosis of chronic myeloid leukemia was made. Treatment with hydroxyurea at a dosage of 18â¯mg/kg twice daily was not effective in controlling the high count of white blood cells. Furthermore, after 35 days of hydroxyurea treatment, the animal developed onycholysis, with sloughing of the claws of the left pelvic and left thoracic limbs and exposure of the distal phalanx. Interruption of the medication was implemented, with clinical healing of the ungual lesions observed three months after initiation of the drug. White blood cells returned to normal after using cyclophosphamide. Currently, the animal is in complete remission, having a disease-free interval of 575 days without chemotherapy. To the authors' knowledge, this is the first report of hydroxyurea-induced onycholysis within a short-term period in a dog diagnosed with chronic myeloid leukemia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Topics in Companion Animal Medicine - Volume 33, Issue 3, September 2018, Pages 73-76
Journal: Topics in Companion Animal Medicine - Volume 33, Issue 3, September 2018, Pages 73-76
نویسندگان
Denner Santos dos Anjos, Paula Barbosa Costa, Larissa Fernandes Magalhães, Oscar Rodrigo Sierra, Sabryna Gouveia Calazans, Carlos Eduardo Fonseca-Alves,