کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8952978 | 1645886 | 2019 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hippo/YAP signaling pathway mitigates blood-brain barrier disruption after cerebral ischemia/reperfusion injury
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کلمات کلیدی
TTCMCAOEBIterminal deoxynucleotidyltransferase-mediated dUTP nick end labelingZO-1DXM2,3,5-triphenyltetrazolium chloride - 2،3،5-trihenyltetrazolium chlorideI/R - I / Rmiddle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیischemia/reperfusion - ایسکمی / رپرفیوژنTUNEL - تونلDexamethasone - دگزامتازونBBB - سد خونی مغزیBlood-brain barrier - مانع خون مغزیSignaling pathway - مسیر سیگنالینگ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Ischemia/reperfusion (I/R) injuries commonly lead to breakdown of the blood-brain barrier (BBB). Restoration of the BBB can relieve neurologic damage caused by I/R injuries. The Hippo/YAP signaling pathway mediates cell proliferation, regulated cell death, and differentiation in various organisms and has been shown to participate in the restoration of the heart after I/R. In this study, we investigated whether the Hippo/YAP pathway plays a role in I/R injury in brain, especially in regard to I/R-induced BBB breakdown. The results of our study indicate that I/R injury led to an overall decrease in activity of the core proteins, YAP and TAZ, over a 24-h period. The most dramatic change was observed 1.5âh after reperfusion. In rats that underwent 1.5âh of reperfusion, intraperitoneal injection of YAP agonist dexamethasone activated YAP and TAZ and led to improved neurologic function, smaller brain infarct sizes, increased levels of tight junction proteins, decreased BBB permeability, decreased cerebral edema, and less apoptosis. Our results suggest that YAP exerts neuroprotective effects on the damaged brain that are likely related to restoration of the BBB.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 356, 1 January 2019, Pages 8-17
Journal: Behavioural Brain Research - Volume 356, 1 January 2019, Pages 8-17
نویسندگان
Pian Gong, Zhan Zhang, Changlin Zou, Qi Tian, Xuemei Chen, Michael Hong, Xi Liu, Qianxue Chen, Zhou Xu, Mingchang Li, Jian Wang,