Role of D-aspartate on biosynthesis, racemization, and potential functions: A mini-review

D-aspartate, a natural and endogenous amino acid, widely exists in animal tissues and can be synthesized through aspartate racemase and transformed by D-aspartate oxidase (DDO). D-aspartate mainly serves as a neurotransmitter and has been demonstrated to exhibit various physiological functions, including nutritional potential, regulation on reproduction and hormone biology, and neuron protection. This article mainly reviews the synthesis, racemization, and physiological functions of D-aspartate with emphasis on the potential in diseases.