کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8962712 1646595 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases
ترجمه فارسی عنوان
پیش بینی های طولانی مدت برای نتیجه روحی آزمایش های قبل از علامت برای بیماری های عصبی دیرپای
کلمات کلیدی
پیش بینی های طولانی مدت، تست قبل از علامت، بیماری های نوروژنیک، تاثیر روانی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی
This longitudinal study aimed at determining predicting variables for middle and long-term psychological disturbance due pre-symptomatic testing (PST) for two late-onset neurological diseases, Huntington disease (HD) and TTR (transthyretin protein) familial amyloid polyneuropathy (FAP) Val30Met (now classified as Val50Met). 196 clinical records of persons who performed PST at least three years ago and answered to the two stages of evaluation (before PST and least 3 years after disclosure of results) were analysed. For this purpose, regression analysis was performed, showing that the Positive Symptom Distress Index (PSDI), psychoticism, somatization and paranoid ideation dimensions assume predictive value in the middle and long-term impact for total anxiety and PSDI. The result of PST was not a relevant predictor. The application of an evaluation instrument of various psychopathological dimensions played a fundamental role in the detection of clinical situations that may arise several years later after PST. Attention should be paid to providing psychological support to persons at-risk who, at the pre-test phase, present some psychopathology indices before pursuing with genetic testing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medical Genetics - Volume 61, Issue 10, October 2018, Pages 575-580
نویسندگان
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